Sister Priscilla Dlamini has founded Holy Cross AIDS Hospice in 1994 in poverty-stricken areas of South Africa, gripped by HIV epidemics, high illiteracy and unemployment rate. The Hospice helps HIV-positive people who have been rejected by hospitals and families and who have no other place to go but to hide in sugarcane plantations to die alone. 

Sister Priscilla heard their cry and established a sanctuary for the sick and dying (36 beds) in order for them to die with peace and dignity. Bereavement counselling and spiritual care, loss/grief counselling to accept death were the main activity. Soon after that, she started a program on Home Based Care where more than 500 women were trained to take care of more than 500 sick people. Those women also identified 3,500 orphaned children from child-headed families and 8,000 people who were to follow the natural method of birth control. Fertility awareness and a dialogue before marital relationship was encouraged and monitored, as men were the ones who were starting the sexual act without considering the partner (rape in disguise).

The organization has built 200 houses for 1,250 child-headed families as well as 4 early childhood centers and 1 feeding center. Open Training Institute for Early Childhood Development educators (450 trained) is under construction. The hospice distributes food parcels and clothing monthly and advocates in schools. 

Sister Priscilla has received numerous awards and accolades, such as 2003 National Woman of the year in Social services, 2010 and 2015 SA Most Influential woman in business and Government and others.