With over 30 years of experience in the field of international development, particularly in Latin America, Ms. Agüero has been part of the professional staff of the Interamerican Development Bank, the World Bank, and the United Nations Development Program, working extensively in these organization's Washington, Uruguay, Geneva, Brussels and Paris offices, and in their field offices. As project officer, sector specialist, and senior adviser in these organizations, she has done considerable project and program work in a number of different areas, most recently in the fields of governance, State reform and civil society – governmental relations. She has also gathered significant experience in relations between international organizations, governmental and non-governmental organizations, national and international partners, and counterparts.

Early in her career, Ms. Agüero was trade policy officer at the U.S. Department of Treasury and research assistant at the Center for Strategic and International Studies in Washington, D.C..