In 1993 Ms. Koirala founded Maiti Nepal with the aim of providing services for both children and women who have endured untold pain and suffering being trafficked within and from Nepal for commercial sexual exploitation.

Maiti Nepal has three prevention homes, nine transit homes, two hospices and a high school. More than one thousand children are getting direct services from Maiti Nepal every day. 

The organization conducts awareness campaigns, community sensitization, rescue operations, apprehending traffickers, provides legal support to the needy, women empowerment programs, provides antiretroviral therapy (ART) to children and women infected by HIV.

So far, Anuradha Koirala has been felicitated with numerous national and international awards in recognition of her courageous acts and lifetime achievement furthering the cause of children’s and women's rights.

Her achievements include liberating twelve thousand girls from brothels, providing ART before the government of Nepal could initiate this process. Due to her continues struggle, Government of Nepal recognized anti trafficking day, which falls on 5 September.

She was the first woman Governor of Federal democratic Republic of Nepal and the only woman member in the government's team to hold peace talks with the then Maoist insurgents of Nepal.